Ferrell* (Dartmouth Medical School at New Hampshire Hospital, Concord, NH)īackground: Psychotropic medicines are used to treat agitation in elderly patients with neuropsychiatric illness. A retrospective study of the use of olanzapine for agitation in elderly patients with dementia and/or other psychiatric illnesses Robert B. Support from NIH Training Grant 5-T32 HD07420-07. Additional study clarifying the effective use of SPECT in DAT differential is needed. Conclusions: SPECT may be a useful diagnostic tool for differential diagnosis of VaD and MDD, but it shows limited utility in differentiating DAT. No significant SPECT differences were found between MDD and DAT patients. Trends were found for right caudate and right global rCBF between VaD and DAT patients (χ 2=2.958, P=0.085, and χ 2=3.788, P=0.052, respectively). Results: Significant SPECT differences were found between MDD and VaD patients in left and right caudate rCBF (Kruskal-Wallis: χ 2=4.418, P=0.036, and χ 2=4.214, P=0.040, respectively), with a trend toward significance in right global rCBF (χ 2=3.718, P=0.054). Subjects were largely Caucasian (90%) women (77%) with a high school education or less (58%). Methods: 39 geropsychiatric patients undergoing neuropsychiatric evaluation received neuropsychological testing and SPECT scans. Differences in SPECT findings within a geropsychiatric population were examined among patients with major depression (MDD), Alzheimer's dementia (DAT), and vascular dementia (VaD). Mountz (University of Alabama at Birmingham Birmingham, AL)īackground: Functional imaging techniques have been used in the differential diagnosis of depression and dementia, although the value of SPECT has been questioned in the literature. Hal Thurstin, George Jewell, Rachael Dowler, Elmer San Pedro, James M. Differences in SPECT findings among geriatric psychiatry patients with major depression, dementia of the Alzheimer's type, and vascular dementia Beverly A. Further research is needed to evaluate the risk for cortical dysfunction posed by white matter disease. Conclusions: Results indicate that WM disease is not a risk factor for poorer cognitive functioning in MDD patients unless there are signs of cortical dysfunction. In contrast, performance of MDD subjects with BWM was better than that of all other groups. An interaction between MDD group and WM findings consistently appeared, with MDDC subjects with BWM more impaired than those without BWM. Expected differences by MDD group were found, with MDDC patients performing less well. Results: Multivariate ANOVAs examined neuropsychological test performance by MDD group and MRI findings. Subjects were predominantly Caucasian (78%) females (87%) who ranged in age from 62 to 89 years. All patients received neuropsychiatric and neuropsychological evaluations. Patients had no changes ( n=10) or bilateral WM changes only (BWM n=13). Methods: 23 MDD patients with diagnoses of MDD only ( n=13), or MDD with cognitive changes (MDDC n=10), were evaluated. The present study examined the impact of WM changes on cognitive functioning in geriatric psychiatry patients. Cleveland Kinney, George Jewell (University of Alabama at Birmingham Birmingham, AL)īackground: White matter (WM) changes on MRI have been associated with risk of major depressive disorder (MDD) in geriatric patients. Neuropsychological performance associated with white matter changes in geropsychiatry patients with major depressive disorder Beverly A. *Corresponding author (if other than the author listed first). The abbreviations defined below are used frequently within the abstracts.ĪD=Alzheimer's disease AIDS=acquired immunodeficiency syndrome ANCOVA=analysis of covariance ANOVA=analysis of variance CGI=Clinical Global Impression CNS=central nervous system CSF=cerebrospinal fluid CT=computed tomography EEG=electroencephalography fMRI=functional MRI GCS=Glasgow Coma Scale HIV=human immunodeficiency virus, type 1 MANOVA=multivariate analysis of variance MMPI=Minnesota Multiphasic Personality Inventory MMSE=Mini-Mental State Examination MRI=magnetic resonance imaging MS=multiple sclerosis MTBI=mild traumatic brain injury NIA=National Institute on Aging NIAAA=National Institute on Alcohol Abuse and Alcoholism NIDRR=National Institute on Disability and Rehabilitation Research NIH=National Institutes of Health NIMH=National Institute of Mental Health NINDS=National Institute of Neurological Disorders and Stroke OCD=obsessive-compulsive disorder PD=Parkinson's disease PET=positron emission tomography QEEG=quantitative electroencephalography rCBF=regional cerebral blood flow SPECT=single-photon emission computed tomography TBI=traumatic brain injury UPDRS=Unified Parkinson's Disease Rating Scale.
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